【佳學(xué)基因檢測(cè)】前庭功能障礙基因檢測(cè)Vestibular dysfunction

基因檢測(cè)機(jī)構(gòu)介紹：

基因檢測(cè)單位名稱(chēng)：新疆維吾爾自治區(qū)烏魯木齊市基因檢測(cè)研究所。其他成熟基因檢測(cè)項(xiàng)目：循環(huán)IgG亞型增加地貧基因檢測(cè)結(jié)果分析, 淋巴細(xì)胞凋亡異常高通量基因檢測(cè)結(jié)果是這樣的！。耳鼻喉科致病基因鑒定基因解碼的研究數(shù)據(jù)表明內(nèi)耳負(fù)責(zé)聽(tīng)力和平衡。 這些功能取決于機(jī)械敏感毛細(xì)胞的正確功能，這些毛細(xì)胞將聲音和運(yùn)動(dòng)引起的刺激轉(zhuǎn)化為傳送到大腦的電信號(hào)。 在內(nèi)耳的進(jìn)化過(guò)程中，聽(tīng)覺(jué)器官發(fā)生了重大變化，而同期所有脊椎動(dòng)物的前庭器官結(jié)構(gòu)保持不變。 由于多種交叉原因：遺傳、環(huán)境因素、耳毒性藥物、感染和衰老，前庭功能障礙在人類(lèi)中非常普遍。 對(duì)與平衡缺陷相關(guān)的耳聾基因及其相應(yīng)動(dòng)物模型的研究揭示了這兩種感覺(jué)系統(tǒng)的發(fā)育和功能。 雙側(cè)前庭功能障礙通常會(huì)損害個(gè)體姿勢(shì)控制、凝視穩(wěn)定、運(yùn)動(dòng)和空間定向。 由此產(chǎn)生的頭暈、眩暈和/或跌倒（在老年人群中很常見(jiàn)）極大地影響了患者的生活質(zhì)量。 在沒(méi)有治療的情況下，前庭植入物等假肢裝置正在開(kāi)發(fā)中，可提供有關(guān)身體運(yùn)動(dòng)的方向、幅度和速度的信息，并在動(dòng)物模型和人類(lèi)身上取得了可喜的成果。 新的方法和技術(shù)已導(dǎo)致針對(duì)內(nèi)耳的基因療法（基因補(bǔ)充和基因編輯）、3D 內(nèi)耳類(lèi)器官和用于生成毛細(xì)胞樣細(xì)胞的重編程方案取得重大進(jìn)展。 涵蓋基礎(chǔ)研究、臨床診斷和治療的多尺度方法的這些快速進(jìn)步正在促進(jìn)跨學(xué)科研究，以開(kāi)發(fā)針對(duì)前庭疾病的個(gè)性化治療。

基因檢測(cè)導(dǎo)讀：

前庭功能障礙基因檢測(cè)的簡(jiǎn)單介紹: 來(lái)自北京市市轄區(qū)豐臺(tái)區(qū)宛平城地區(qū)的郭偉倫（化名）在廣西民族醫(yī)院南寧地區(qū)人民醫(yī)院被醫(yī)生診斷為前庭功能障礙?！禔dvances in Oto-Rhino-Laryngology》臨床討化，前庭功能障礙的出現(xiàn)有多種原因，其中一個(gè)重要的原因是基因突變，這需要通過(guò)基因檢測(cè)來(lái)明確?；蛲蛔円鸬目赡軙?huì)遺傳。

本文關(guān)鍵詞

前庭,功能障礙,基因檢測(cè)

人體疾病表征數(shù)據(jù)庫(kù)查詢(xún)

產(chǎn)生前庭功能障礙醫(yī)師會(huì)懷疑以下疾病類(lèi)型：

怎樣才能診斷正確？

HP:0001751

表型描述

An abnormality of the functioning of the vestibular apparatus.The inner ear is responsible for both hearing and balance. These functions are dependent on the correct functioning of mechanosensitive hair cells, which convert sound- and motion-induced stimuli into electrical signals conveyed to the brain. During evolution of the inner ear, the major changes occurred in the hearing organ, whereas the structure of the vestibular organs remained constant in all vertebrates over the same period. Vestibular deficits are highly prevalent in humans, due to multiple intersecting causes: genetics, environmental factors, ototoxic drugs, infections and aging. Studies of deafness genes associated with balance deficits and their corresponding animal models have shed light on the development and function of these two sensory systems. Bilateral vestibular deficits often impair individual postural control, gaze stabilization, locomotion and spatial orientation. The resulting dizziness, vertigo, and/or falls (frequent in elderly populations) greatly affect patient quality of life. In the absence of treatment, prosthetic devices, such as vestibular implants, providing information about the direction, amplitude and velocity of body movements, are being developed and have given promising results in animal models and humans. Novel methods and techniques have led to major progress in gene therapies targeting the inner ear (gene supplementation and gene editing), 3D inner ear organoids and reprograming protocols for generating hair cell-like cells. These rapid advances in multiscale approaches covering basic research, clinical diagnostics and therapies are fostering interdisciplinary research to develop personalized treatments for vestibular disorders.