【佳學(xué)基因檢測(cè)】遺傳學(xué)和基因組學(xué)在臨床精神病學(xué)中的作用

精神病基因檢測(cè)哪家醫(yī)院最好解析

閱讀精神病的正確化治療及靶向藥物選擇發(fā)現(xiàn)《Dialogues Clin Neurosci》在.?2018 Sep;20(3):169-177.發(fā)表了一篇題目為《遺傳學(xué)和基因組學(xué)在臨床精神病學(xué)中的作用》腫瘤靶向藥物治療基因檢測(cè)臨床研究文章。該研究由Margret R Hoehe, Deborah J Morris-Rosendahl等完成。促進(jìn)了腫瘤的正確治療與個(gè)性化用藥的發(fā)展，進(jìn)一步強(qiáng)調(diào)了基因信息檢測(cè)與分析的重要性。

遺傳力、發(fā)病原因及正確治療臨床研究?jī)?nèi)容關(guān)鍵詞：

神經(jīng)科用藥指導(dǎo)基因檢測(cè)臨床應(yīng)用結(jié)果

許多疾病的遺傳學(xué)和基因組學(xué)取得的巨大成功為正確醫(yī)學(xué)的進(jìn)步奠定了基礎(chǔ)。因此，與神經(jīng)精神疾病以及治療結(jié)果相關(guān)的基因變異的檢測(cè)已經(jīng)引起了人們?cè)絹?lái)越多的期望，即這些發(fā)現(xiàn)可以很快轉(zhuǎn)化為臨床，以改善診斷、疾病風(fēng)險(xiǎn)的預(yù)測(cè)和個(gè)體對(duì)藥物治療的反應(yīng)。在本文中，我們將介紹尋找與精神疾病有關(guān)的基因，并總結(jié)目前在主要精神疾病中的發(fā)現(xiàn)。我們將回顧編碼藥物代謝酶和特定藥物靶標(biāo)的基因中的遺傳變異，這些變異被發(fā)現(xiàn)與可變的藥物反應(yīng)和嚴(yán)重的副作用有關(guān)。我們將評(píng)估這些發(fā)現(xiàn)的臨床可翻譯性，目前是否有基因檢測(cè)的任何作用，并在這種情況下，為臨床醫(yī)生提供有價(jià)值的信息來(lái)源，以便在這個(gè)快速發(fā)展的精神遺傳學(xué)領(lǐng)域?qū)で笾笇?dǎo)和建議。關(guān)鍵詞：基因檢測(cè);遺傳學(xué)；基因組學(xué)；藥物基因組學(xué)；精神障礙。

神經(jīng)及精神疾病及其并發(fā)征、合并征國(guó)際數(shù)據(jù)庫(kù)描述：

The enormous successes in the genetics and genomics of many diseases have provided the basis for the advancement of precision medicine. Thus, the detection of genetic variants associated with neuropsychiatric disorders, as well as treatment outcome, has raised growing expectations that these findings could soon be translated into the clinic to improve diagnosis, the prediction of disease risk and individual response to drug therapy. In this article, we will provide an introduction to the search for genes involved in psychiatric illness and summarize the present findings in major psychiatric disorders. We will review the genetic variants in genes encoding drug metabolizing enzymes and specific drug targets which were found to be associated with variable drug response and severe side effects. We will evaluate the clinical translatability of these findings, whether there is currently any role for genetic testing and in this context, make valuable sources of information available to the clinician seeking guidance and advice in this rapidly developing field of psychiatric genetics.Keywords:?genetic testing; genetics; genomics; pharmacogenomics; psychiatric disorder.

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