【佳學基因檢測】精神病學遺傳學史前史：1780-1910

基因測序的費用大概多少錢省錢要點

查重分析高效抑制神經科疾病轉移的方法與藥物《精神與神經疾病致病基因突變位點的性質及影響分析》《Am J Psychiatry》在.?2021 Jun;178(6):490-508.發(fā)表了一篇題目為《精神病學遺傳學史前史：1780-1910》腫瘤靶向藥物治療基因檢測臨床研究文章。該研究由Kenneth S Kendler等完成。促進了腫瘤的正確治療與個性化用藥的發(fā)展，進一步強調了基因信息檢測與分析的重要性。

神經疾病遺傳阻斷及正確治療臨床研究內容關鍵詞：

神經科用藥指導基因檢測臨床應用結果

雖然精神遺傳學已成為我們賊具活力的研究領域之一，但我們看待這些發(fā)展的歷史背景是有限的。為了提供這樣的視角，作者回顧了 1780 年至 1910 年間出版的 48 篇代表性文本，考察了精神錯亂的遺傳。出現(xiàn)了六個主要結論。首先，大多數(shù)作者認為遺傳是精神錯亂的賊強風險因素之一。其次，大多數(shù)作者得出結論認為，疾病傾向而不是疾病本身是在家庭中傳播的。第三，人們注意到了傳播的概率性質，因為精神錯亂通常會跨越幾代人或僅影響許多兄弟姐妹中的少數(shù)人。第四，作者討論了各種形式的精神錯亂的家庭傳播的同質性與異質性。異質性傳播通常被視為患有各種精神疾病，有時甚至是神經疾病的精神病患者的親屬的規(guī)則。同質傳輸（“l(fā)ike begets like”）是個例外。第五，作者指出，古怪和古怪的人格特征在精神病患者的親屬中很常見。賊后，遺傳通常被理解為包括父母先前的環(huán)境經歷，一些作者指出，精神錯亂的父母-后代傳播可能來自心理或宮內影響。許多這些結論僅來自臨床經驗，沒有對生物學機制、統(tǒng)計分析或必要控制的理解，得到了后來更嚴格的方法的支持。與其有效拒絕它的價值，我們可能會將這些文獻視為一種補充資源，可能更有偏見，但充斥著我們前輩廣泛的臨床知識。精神病學遺傳學。

神經及精神疾病及其并發(fā)征、合并征國際數(shù)據(jù)庫描述：

While psychiatric genetics has emerged as one of our most dynamic research fields, the historical context in which we view these developments is limited. To provide such a perspective, the author reviews 48 representative texts, published from 1780 to 1910, examining the inheritance of insanity. Six main conclusions emerge. First, most authors viewed heredity as among the strongest risk factors for insanity. Second, most writers concluded that a predisposition to illness rather than the illness itself was transmitted in families. Third, the probabilistic nature of the transmission was noted, as insanity often skipped generations or affected only a few of many siblings. Fourth, authors discussed the homogeneity versus heterogeneity of familial transmission of the various forms of insanities. Heterogeneous transmission was usually seen as the rule-with relatives of insane patients affected with a wide variety of psychiatric, and sometimes neurological, illnesses. Homogeneous transmission ("like begets like") was the exception. Fifth, writers noted that odd and eccentric personality features were common in the relatives of their insane patients. Finally, inheritance was commonly understood to include prior environmental parental experiences, and some authors noted that parent-offspring transmission of insanity could arise from psychological or intrauterine effects. Many of these conclusions, arising solely from clinical experience and without an understanding of biological mechanisms, statistical analyses, or necessary controls, are supported by later, more rigorous methods. Rather than entirely rejecting its value, we might view this literature as a complementary resource, likely more biased, but suffused with the extensive clinical knowledge of our forebears.Keywords:?History of Psychiatry; Psychiatric Genetics.