【佳學(xué)基因檢測(cè)】線粒體轉(zhuǎn)運(yùn)蛋白在癌癥中的表達(dá)和推測(cè)作用
腫瘤基因檢測(cè)多少錢一次—目標(biāo)
在基因檢測(cè)小組討論中,得知《腫瘤致病基因突變位點(diǎn)的性質(zhì)及影響分析》《Biochim Biophys Acta Bioenerg》在?2017 Aug;1858(8):641-654發(fā)表了一篇題目為《線粒體轉(zhuǎn)運(yùn)蛋白在癌癥中的表達(dá)和推測(cè)作用》腫瘤靶向藥物治療基因檢測(cè)臨床研究文章。該研究由Oleksandr Lytovchenko,?Edmund R S Kunji?等完成。促進(jìn)了腫瘤的正確治療與個(gè)性化用藥的發(fā)展,進(jìn)一步強(qiáng)調(diào)了基因信息檢測(cè)與分析的重要性。
腫瘤靶向藥物及正確治療臨床研究內(nèi)容關(guān)鍵詞:
癌癥代謝,線粒體載體,線粒體代謝,丙酮酸載體,癌癥調(diào)節(jié),運(yùn)輸者。
腫瘤靶向治療基因檢測(cè)臨床應(yīng)用結(jié)果
癌細(xì)胞在能量和生物合成代謝方面發(fā)生重大變化。其中之一是 Warburg 效應(yīng),其中丙酮酸用于發(fā)酵而不是氧化磷酸化。另一個(gè)主要問題是他們對(duì)谷氨酰胺的依賴增加,這有助于補(bǔ)充用于其他目的的克雷布斯循環(huán)代謝物庫,例如氨基酸或脂質(zhì)生物合成。線粒體是這些改變的核心,因?yàn)檫B接這些過程的生化途徑貫穿這些細(xì)胞器。兩個(gè)膜,一個(gè)外膜和一個(gè)內(nèi)膜,圍繞著線粒體,后者對(duì)大多數(shù)有機(jī)化合物是不可滲透的。因此,需要大量的轉(zhuǎn)運(yùn)蛋白來連接胞質(zhì)溶膠和線粒體基質(zhì)的生化途徑。由于運(yùn)輸步驟相對(duì)緩慢,預(yù)計(jì)當(dāng)細(xì)胞癌變時(shí),許多運(yùn)輸步驟會(huì)發(fā)生改變。在這篇綜述中,討論了這些轉(zhuǎn)運(yùn)蛋白的表達(dá)和調(diào)控的變化以及轉(zhuǎn)運(yùn)底物的作用。本文是由 Giuseppe Gasparre、Rodrigue Rossignol 和 Pierre Sonveaux 編輯的題為“癌癥中的線粒體”的特刊的一部分。
腫瘤發(fā)生與反復(fù)轉(zhuǎn)移國際數(shù)據(jù)庫描述:
Cancer cells undergo major changes in energy and biosynthetic metabolism. One of them is the Warburg effect, in which pyruvate is used for fermentation rather for oxidative phosphorylation. Another major one is their increased reliance on glutamine, which helps to replenish the pool of Krebs cycle metabolites used for other purposes, such as amino acid or lipid biosynthesis. Mitochondria are central to these alterations, as the biochemical pathways linking these processes run through these organelles. Two membranes, an outer and inner membrane, surround mitochondria, the latter being impermeable to most organic compounds. Therefore, a large number of transport proteins are needed to link the biochemical pathways of the cytosol and mitochondrial matrix. Since the transport steps are relatively slow, it is expected that many of these transport steps are altered when cells become cancerous. In this review, changes in expression and regulation of these transport proteins are discussed as well as the role of the transported substrates. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux.
(責(zé)任編輯:佳學(xué)基因)