【佳學(xué)基因檢測(cè)】自殺基因治療的背景、原理和賊新技術(shù)簡(jiǎn)介

做完基因檢測(cè) 我后悔了—科學(xué)性

查重分析《腫瘤個(gè)性治療的方法與措施》《Mol Biotechnol》在?2005 May;30(1):71-88發(fā)表了一篇題目為《自殺基因治療的背景、原理和賊新技術(shù)簡(jiǎn)介》腫瘤靶向藥物治療基因檢測(cè)臨床研究文章。該研究由Ion Niculescu-Duvaz,?Caroline J Springer等完成。促進(jìn)了腫瘤的正確治療與個(gè)性化用藥的發(fā)展，進(jìn)一步強(qiáng)調(diào)了基因信息檢測(cè)與分析的重要性。

腫瘤靶向藥物及正確治療臨床研究?jī)?nèi)容關(guān)鍵詞：

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腫瘤靶向治療基因檢測(cè)臨床應(yīng)用結(jié)果

基因治療被定義為旨在修改細(xì)胞的遺傳成分以獲得治療益處的技術(shù)。自殺基因療法（或基因?qū)虻拿盖八幆煼?[GDEPT]）是癌癥（尤其是實(shí)體瘤）的兩步療法。在先進(jìn)步中，外源酶的基因通過(guò)載體遞送至腫瘤。在外源酶表達(dá)后，在第二步中給予前藥，該前藥在腫瘤中被選擇性激活。本文討論了GDEPT的原理和理論背景。特別強(qiáng)調(diào)為 GDEPT 開(kāi)發(fā)的酶/前藥系統(tǒng)、前藥的設(shè)計(jì)及其激活動(dòng)力學(xué)、旁觀者效應(yīng)的類(lèi)型和機(jī)制及其免疫學(xué)意義。還討論了改進(jìn) GDEPT 的可能策略。

腫瘤發(fā)生與反復(fù)轉(zhuǎn)移國(guó)際數(shù)據(jù)庫(kù)描述：

Gene therapy is defined as a technology that aims to modify the genetic component of cells to gain therapeutic benefits. Suicide gene therapy (or gene-directed enzyme prodrug therapy [GDEPT]) is a two-step treatment for cancer (especially, solid tumors). In the first step, a gene for a foreign enzyme is delivered to the tumor by a vector. Following the expression of the foreign enzyme, a prodrug is administered during the second step, which is selectively activated in the tumor. This article discusses the principles and the theorectical background of GDEPT. A special emphasis is put on enzyme/prodrug systems developed for GDEPT, the design of prodrugs and the kinetic of their activation, the types and the mechanisms of bystander effect and its immunological implications. The possible strategies to improve GDEPT are also discussed.