【佳學(xué)基因檢測】吸毒成癮：一種可治好的精神障礙？

精神病基因檢測19800元導(dǎo)讀

根據(jù)精神病治療的前沿研究知道《Acta Pharmacol Sin》在.?2018 Dec;39(12):1823-1829.發(fā)表了一篇題目為《吸毒成癮：一種可治好的精神障礙？》腫瘤靶向藥物治療基因檢測臨床研究文章。該研究由Jian-Feng Liu, Jun-Xu Li等完成。促進(jìn)了腫瘤的正確治療與個性化用藥的發(fā)展，進(jìn)一步強(qiáng)調(diào)了基因信息檢測與分析的重要性。

遺傳力、發(fā)病原因及正確治療臨床研究內(nèi)容關(guān)鍵詞：

生物標(biāo)志物,遺傳學(xué)

神經(jīng)科用藥指導(dǎo)基因檢測臨床應(yīng)用結(jié)果

吸毒成癮是一種慢性、反反復(fù)作的腦部疾病。大腦中的多個神經(jīng)網(wǎng)絡(luò)，包括獎賞系統(tǒng)（例如，中腦邊緣系統(tǒng)）、抗獎賞/壓力系統(tǒng)（例如，擴(kuò)展的杏仁核）和中樞免疫系統(tǒng)，都參與了藥物成癮和吸毒后反復(fù)的發(fā)展。戒除濫用藥物。臨床前和臨床研究表明，通過藥理學(xué)靶向大腦中與成癮相關(guān)的系統(tǒng)來控制藥物成癮是有希望的。在這里，我們回顧了具有臨床意義的多巴胺系統(tǒng)、谷氨酸系統(tǒng)、微量胺系統(tǒng)、抗獎賞系統(tǒng)和中樞免疫系統(tǒng)內(nèi)的藥理學(xué)靶點(diǎn)。此外，我們討論了其他潛在的療法，例如腦刺激、行為療法和治療性基因調(diào)節(jié)，它們可能對治療藥物成癮有效。我們的結(jié)論是，雖然吸毒成癮是一種復(fù)雜的疾病，涉及復(fù)雜的神經(jīng)機(jī)制和心理過程，但這種精神疾病是可以治療的，未來可能通過基因調(diào)控等療法治好。腦刺激；吸毒成癮；基因治療;藥理靶點(diǎn)。

神經(jīng)及精神疾病及其并發(fā)征、合并征國際數(shù)據(jù)庫描述：

Drug addiction is a chronic, relapsing brain disorder. Multiple neural networks in the brain including the reward system (e.g., the mesocorticolimbic system), the anti-reward/stress system (e.g., the extended amygdala), and the central immune system, are involved in the development of drug addiction and relapse after withdrawal from drugs of abuse. Preclinical and clinical studies have demonstrated that it is promising to control drug addiction by pharmacologically targeting the addiction-related systems in the brain. Here we review the pharmacological targets within the dopamine system, glutamate system, trace amine system, anti-reward system, and central immune system, which are of clinical interests. Furthermore, we discuss other potential therapies, e.g., brain stimulation, behavioral treatments, and therapeutic gene modulation, which could be effective to treat drug addiction. We conclude that, although drug addiction is a complex disorder that involves complicated neural mechanisms and psychological processes, this mental disorder is treatable and may be curable by therapies such as gene modulation in the future.Keywords:?behavioral treatment; brain stimulation; drug addiction; gene therapy; pharmacological targets.