【佳學(xué)基因檢測】多模認(rèn)知模型中CHRM2的知識(shí)構(gòu)建框架
基因檢測的序列名稱:
CHRM2
人體基因序列變化與疾病表征數(shù)據(jù)庫中的基因代碼:
1129
人體基因序列數(shù)據(jù)庫中國際交流名稱全稱
cholinergic receptor muscarinic 2
中國數(shù)據(jù)庫中基因全稱:
膽堿能受體毒蕈堿2
基因檢測報(bào)告英文版基因簡介
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
基因突變所影響的基因信息
毒蕈堿膽堿能受體屬于更大的G蛋白偶聯(lián)受體家族。這些受體的功能多樣性由乙酰膽堿與這些受體的結(jié)合來定義,并且包括細(xì)胞反應(yīng),例如腺苷酸環(huán)化酶抑制,磷酸肌醇變性和鉀通道介導(dǎo)。毒蕈堿受體影響乙酰膽堿在中樞神經(jīng)系統(tǒng)和周圍神經(jīng)系統(tǒng)中的多種作用。毒蕈堿膽堿能受體2參與心動(dòng)過緩的介導(dǎo)和心臟收縮力的降低。已經(jīng)為該基因描述了多個(gè)選擇性剪??接的轉(zhuǎn)錄物變體。[由RefSeq提供,2008年7月]
國際國內(nèi)該堿基基因序列的其他英語文字母簡稱:
HM2
基因解碼對(duì)該基因序列在細(xì)胞核中的染色體所給予的編號(hào):
該基因序列位于人類第7號(hào)染色體上。
基因解碼對(duì)基因序列的正確定位
該基因序列在GRCh37版本中的起始位置坐標(biāo)為:136553399;結(jié)束位置坐標(biāo)為:136703720。該基因序列在GRCh38版本中的起始位置坐標(biāo)為:136868652;結(jié)束位置坐標(biāo)為:137020255。正確的基因信息定位是基因檢測和對(duì)檢測結(jié)果進(jìn)行正確解讀的關(guān)鍵。
佳學(xué)基因解碼對(duì)該基因的功能分類:國際版
G-protein coupled receptors/GPCRs excl olfactory receptors
基因解碼對(duì)該基因的功能分類:中文版
G 蛋白偶聯(lián)受體/GPCR 不包括嗅覺受體
結(jié)構(gòu)與功能基因解碼所揭示的該基因在細(xì)胞內(nèi)發(fā)揮作用的場所(國際版):
正在通過基因解碼技術(shù)進(jìn)行收集、查證并編輯,請(qǐng)關(guān)注佳學(xué)基因,獲得及時(shí)更新的人類基因序列變化與疾病表征數(shù)據(jù)庫的更新內(nèi)容
結(jié)構(gòu)與功能基因解碼所揭示的該基因發(fā)揮作用的細(xì)胞內(nèi)位置(中文版):
正在通過基因解碼技術(shù)進(jìn)行收集、查證并編輯,請(qǐng)關(guān)注佳學(xué)基因,獲得及時(shí)更新的人類基因序列變化與疾病表征數(shù)據(jù)庫的更新內(nèi)容
該基因序列變化后增加的疾病風(fēng)險(xiǎn)(國際版):
Neurogenic Urinary Bladder; Diabetic Neuropathies; Bradycardia; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Experimental; Substance-Related Disorders; Mood Disorders; Mental Depression; Alcoholic Intoxication, Chronic; Depressive disorder; Bipolar Disorder; Epilepsy; Schizophrenia
如果該基因突變后,風(fēng)險(xiǎn)可能增加的疾病類型(中文版):
神經(jīng)源性膀胱;糖尿病性神經(jīng)??;心動(dòng)過緩;糖尿病胰島素依賴性;糖尿病實(shí)驗(yàn)性的;物質(zhì)相關(guān)疾?。磺榫w障礙;精神抑郁癥;酒精中毒慢性;抑郁癥;躁郁癥;癲癇;精神分裂癥
GWAS基因檢測所建立的與該基因的疾病關(guān)聯(lián)(國際版):
正在通過基因解碼技術(shù)進(jìn)行收集、查證并編輯,請(qǐng)關(guān)注佳學(xué)基因,獲得及時(shí)更新的人類基因序列變化與疾病表征數(shù)據(jù)庫的更新內(nèi)容
GWAS基因檢測所解碼的該基因突變會(huì)增加風(fēng)險(xiǎn)的疾病種類(中文版):
正在通過基因解碼技術(shù)進(jìn)行收集、查證并編輯,請(qǐng)關(guān)注佳學(xué)基因,獲得及時(shí)更新的人類基因序列變化與疾病表征數(shù)據(jù)庫的更新內(nèi)容
以該基因做靶點(diǎn)的藥物(國際版):
Succinylcholine (G-protein coupled acetylcholine receptor activity);Ziprasidone (G-protein coupled acetylcholine receptor activity);Disopyramide (G-protein coupled acetylcholine receptor activity);Amitriptyline (G-protein coupled acetylcholine receptor activity);Ipratropium bromide (G-protein coupled acetylcholine receptor activity);Olanzapine (G-protein coupled acetylcholine receptor activity);Metixene (G-protein coupled acetylcholine receptor activity);Terfenadine (G-protein coupled acetylcholine receptor activity);Clozapine (G-protein coupled acetylcholine receptor activity);Trihexyphenidyl (G-protein coupled acetylcholine receptor activity);Oxyphencyclimine (G-protein coupled acetylcholine receptor activity);Procyclidine (G-protein coupled acetylcholine receptor activity);Ethopropazine (G-protein coupled acetylcholine receptor activity);Loxapine (G-protein coupled acetylcholine receptor activity);Carbachol (G-protein coupled acetylcholine receptor activity);Promazine (G-protein coupled acetylcholine receptor activity);Hyoscyamine (G-protein coupled acetylcholine receptor activity);Cyproheptadine (G-protein coupled acetylcholine receptor activity);Imipramine (G-protein coupled acetylcholine receptor activity);Methylscopolamine bromide (G-protein coupled acetylcholine receptor activity);Gallamine Triethiodide (G-protein coupled acetylcholine receptor activity);Darifenacin (G-protein coupled acetylcholine receptor activity);Tridihexethyl (G-protein coupled acetylcholine receptor activity);Triflupromazine (G-protein coupled acetylcholine receptor activity);Anisotropine Methylbromide (G-protein coupled acetylcholine receptor activity);Nortriptyline (G-protein coupled acetylcholine receptor activity);Atropine (G-protein coupled acetylcholine receptor activity);Nicardipine (G-protein coupled acetylcholine receptor activity);Paroxetine (G-protein coupled acetylcholine receptor activity);Homatropine Methylbromide (G-protein coupled acetylcholine receptor activity);Rocuronium (G-protein coupled acetylcholine receptor activity);Scopolamine (G-protein coupled acetylcholine receptor activity);Benzquinamide (G-protein coupled acetylcholine receptor activity);Propiomazine (G-protein coupled acetylcholine receptor activity);Cryptenamine (G-protein coupled acetylcholine receptor activity);Dicyclomine (G-protein coupled acetylcholine receptor activity);Tropicamide (G-protein coupled acetylcholine receptor activity);Brompheniramine (G-protein coupled acetylcholine receptor activity);Cocaine (G-protein coupled acetylcholine receptor activity);Maprotiline (G-protein coupled acetylcholine receptor activity);Glycopyrronium (G-protein coupled acetylcholine receptor activity);Bethanechol (G-protein coupled acetylcholine receptor activity);Tolterodine (G-protein coupled acetylcholine receptor activity);Oxybutynin (G-protein coupled acetylcholine receptor activity);Promethazine (G-protein coupled acetylcholine receptor activity);Diphenhydramine (G-protein coupled acetylcholine receptor activity);Pilocarpine (G-protein coupled acetylcholine receptor activity);Doxacurium chloride (G-protein coupled acetylcholine receptor activity);Doxepin (G-protein coupled acetylcholine receptor activity);Flavoxate (G-protein coupled acetylcholine receptor activity);Desipramine (G-protein coupled acetylcholine receptor activity);Quetiapine (G-protein coupled acetylcholine receptor activity);Mivacurium (G-protein coupled acetylcholine receptor activity);Diphenidol (G-protein coupled acetylcholine receptor activity);Aripiprazole (G-protein coupled acetylcholine receptor activity);Chlorprothixene (G-protein coupled acetylcholine receptor activity);Metocurine (G-protein coupled acetylcholine receptor activity);Pancuronium (G-protein coupled acetylcholine receptor activity);Pipecuronium (G-protein coupled acetylcholine receptor activity);Methotrimeprazine (G-protein coupled acetylcholine receptor activity);Tiotropium (G-protein coupled acetylcholine receptor activity);Solifenacin (G-protein coupled acetylcholine receptor activity);ALKS 27 (G-protein coupled acetylcholine receptor activity);Fesoterodine (G-protein coupled acetylcholine receptor activity);Dimetindene (G-protein coupled acetylcholine receptor activity);Aclidinium (G-protein coupled acetylcholine receptor activity);Umeclidinium (G-protein coupled acetylcholine receptor activity)
針對(duì)該基因所產(chǎn)生的突變,可能有正確效果的藥物(中文版):
琥珀膽堿(G 蛋白偶聯(lián)乙酰膽堿受體活性);齊拉西酮(G 蛋白偶聯(lián)乙酰膽堿受體活性);丙吡胺(G 蛋白偶聯(lián)乙酰膽堿受體活性);阿米替林(G 蛋白偶聯(lián)乙酰膽堿受體活性);異丙托溴銨(G 蛋白偶聯(lián)受體活性)偶聯(lián)乙酰膽堿受體活性);奧氮平(G 蛋白偶聯(lián)乙酰膽堿受體活性);Metixene(G 蛋白偶聯(lián)乙酰膽堿受體活性);特非那定(G 蛋白偶聯(lián)乙酰膽堿受體活性);氯氮平(G 蛋白偶聯(lián)乙酰膽堿受體活性);苯海索(G 蛋白偶聯(lián)乙酰膽堿受體活性);羥苯環(huán)亞胺(G 蛋白偶聯(lián)乙酰膽堿受體活性);丙環(huán)利定(G 蛋白偶聯(lián)乙酰膽堿受體活性);乙丙嗪(G 蛋白偶聯(lián)乙酰膽堿受體活性);洛沙平(G 蛋白偶聯(lián)乙酰膽堿受體活性)乙酰膽堿受體活性);卡巴膽堿(G 蛋白偶聯(lián)乙酰膽堿受體活性);異丙嗪(G 蛋白偶聯(lián)乙酰膽堿受體活性);芍藥堿(G 蛋白偶聯(lián)乙酰膽堿受體活性);賽庚啶(G 蛋白偶聯(lián)乙酰膽堿受體活性);丙咪嗪(G 蛋白偶聯(lián)乙酰膽堿受體活性);甲基東莨菪堿溴化物(G 蛋白偶聯(lián)乙酰膽堿受體活性);加拉敏三硫碘化物(G 蛋白偶聯(lián)乙酰膽堿受體活性);達(dá)非那新(G 蛋白偶聯(lián)乙酰膽堿受體活性);Tridihexethyl(G 蛋白偶聯(lián)乙酰膽堿受體活性)偶聯(lián)乙酰膽堿受體活性);三氟丙嗪(G 蛋白偶聯(lián)乙酰膽堿受體活性);異丙嗪(G 蛋白偶聯(lián)乙酰膽堿受體活性);去甲替林(G 蛋白偶聯(lián)乙酰膽堿受體活性);阿托品(G 蛋白偶聯(lián)乙酰膽堿受體活性) ;尼卡地平(G 蛋白偶聯(lián)乙酰膽堿受體活性);帕羅西?。℅ 蛋白偶聯(lián)乙酰膽堿受體活性);后馬托品甲基溴(G 蛋白偶聯(lián)乙酰膽堿受體活性);羅庫溴銨(G 蛋白偶聯(lián)乙酰膽堿受體活性);東莨菪堿(G-蛋白偶聯(lián)乙酰膽堿受體活性);Benzquinamide(G 蛋白偶聯(lián)乙酰膽堿受體活性);Propiomazine(G 蛋白偶聯(lián)乙酰膽堿受體活性);Cryptenamine(G 蛋白偶聯(lián)乙酰膽堿受體活性);雙環(huán)胺(G 蛋白偶聯(lián)乙酰膽堿受體活性) ;托吡卡胺(G 蛋白偶聯(lián)乙酰膽堿受體活性);溴苯那敏(G 蛋白偶聯(lián)乙酰膽堿受體活性);可卡因(G 蛋白偶聯(lián)乙酰膽堿受體活性);馬普替林(G 蛋白偶聯(lián)乙酰膽堿受體活性);格隆銨(G 蛋白偶聯(lián)偶聯(lián)乙酰膽堿受體活性);Bethanchol(G 蛋白偶聯(lián)乙酰膽堿受體活性);托特羅定(G 蛋白偶聯(lián)乙酰膽堿受體活性);奧昔布寧(G 蛋白偶聯(lián)乙酰膽堿受體活性);異丙嗪(G 蛋白偶聯(lián)乙酰膽堿受體活性);苯海拉明(G 蛋白偶聯(lián)乙酰膽堿受體活性);毛果蕓香堿(G 蛋白偶聯(lián)乙酰膽堿受體活性);多沙庫氯銨(G 蛋白偶聯(lián)乙酰膽堿受體活性);多慮平(G 蛋白偶聯(lián)乙酰膽堿受體活性);黃酮酸鹽(G 蛋白偶聯(lián)受體活性)偶聯(lián)乙酰膽堿受體活性);地昔帕明(G 蛋白偶聯(lián)乙酰膽堿受體活性);喹硫平(G 蛋白偶聯(lián)乙酰膽堿受體活性);米庫氯銨(G 蛋白偶聯(lián)乙酰膽堿受體活性);地苯尼多(G 蛋白偶聯(lián)乙酰膽堿受體活性);阿立哌唑(G 蛋白偶聯(lián)乙酰膽堿受體活性);氯丙噻噸(G 蛋白偶聯(lián)乙酰膽堿受體活性);美托庫林(G 蛋白偶聯(lián)乙酰膽堿受體活性);泮庫溴銨(G 蛋白偶聯(lián)乙酰膽堿受體活性);哌庫溴銨(G 蛋白偶聯(lián)乙酰膽堿受體活性)乙酰膽堿受體活性);甲氧美拉嗪(G 蛋白偶聯(lián)乙酰膽堿受體活性);噻托溴銨(G 蛋白偶聯(lián)乙酰膽堿受體活性);索利那新(G 蛋白偶聯(lián)乙酰膽堿受體活性);ALKS 27(G 蛋白偶聯(lián)乙酰膽堿受體活性);非索羅定(G 蛋白偶聯(lián)乙酰膽堿受體活性);二甲茚(G 蛋白偶聯(lián)乙酰膽堿受體活性);阿地溴銨(G 蛋白偶聯(lián)乙酰膽堿受體活性);烏美溴銨(G 蛋白偶聯(lián)乙酰膽堿受體活性)
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