【佳學(xué)基因檢測(cè)】全基因測(cè)序CHRM4基因篩查有意義未明突變，我該怎么辦？

基因檢測(cè)的序列名稱：

CHRM4

人體基因序列變化與疾病表征數(shù)據(jù)庫(kù)中的基因代碼：

1132

人體基因序列數(shù)據(jù)庫(kù)中國(guó)際交流名稱全稱

cholinergic receptor muscarinic 4

中國(guó)數(shù)據(jù)庫(kù)中基因全稱：

膽堿能受體毒蕈堿4

基因檢測(cè)報(bào)告英文版基因簡(jiǎn)介

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]

基因突變所影響的基因信息

毒蕈堿膽堿能受體屬于更大的G蛋白偶聯(lián)受體家族。這些受體的功能多樣性由乙酰膽堿的結(jié)合決定，包括細(xì)胞反應(yīng)，例如腺苷酸環(huán)化酶抑制，磷酸肌醇變性和鉀通道介導(dǎo)。毒蕈堿受體影響乙酰膽堿在中樞神經(jīng)系統(tǒng)和周圍神經(jīng)系統(tǒng)中的多種作用。該受體的臨床意義尚不清楚。然而，小鼠研究將其功能與腺苷酸環(huán)化酶抑制聯(lián)系起來。[由RefSeq提供，2008年7月]

國(guó)際國(guó)內(nèi)該堿基基因序列的其他英語(yǔ)文字母簡(jiǎn)稱：

HM4, M4R

基因解碼對(duì)該基因序列在細(xì)胞核中的染色體所給予的編號(hào)：

該基因序列位于人類第11號(hào)染色體上。

基因解碼對(duì)基因序列的正確定位

該基因序列在GRCh37版本中的起始位置坐標(biāo)為：46405335；結(jié)束位置坐標(biāo)為：46413122。該基因序列在GRCh38版本中的起始位置坐標(biāo)為：46384792；結(jié)束位置坐標(biāo)為：46386608。正確的基因信息定位是基因檢測(cè)和對(duì)檢測(cè)結(jié)果進(jìn)行正確解讀的關(guān)鍵。

佳學(xué)基因解碼對(duì)該基因的功能分類：國(guó)際版

G-protein coupled receptors/GPCRs excl olfactory receptors

基因解碼對(duì)該基因的功能分類：中文版

G 蛋白偶聯(lián)受體/GPCR 不包括嗅覺受體

結(jié)構(gòu)與功能基因解碼所揭示的該基因在細(xì)胞內(nèi)發(fā)揮作用的場(chǎng)所（國(guó)際版）：

Golgi apparatus;Nucleus

結(jié)構(gòu)與功能基因解碼所揭示的該基因發(fā)揮作用的細(xì)胞內(nèi)位置（中文版）：

高爾基體；細(xì)胞核

該基因序列變化后增加的疾病風(fēng)險(xiǎn)（國(guó)際版）：

Catatonia; Tremor; Schizophrenia

如果該基因突變后，風(fēng)險(xiǎn)可能增加的疾病類型（中文版）：

緊張癥;震顫;精神分裂癥

GWAS基因檢測(cè)所建立的與該基因的疾病關(guān)聯(lián)（國(guó)際版）：

正在通過基因解碼技術(shù)進(jìn)行收集、查證并編輯，請(qǐng)關(guān)注佳學(xué)基因，獲得及時(shí)更新的人類基因序列變化與疾病表征數(shù)據(jù)庫(kù)的更新內(nèi)容

GWAS基因檢測(cè)所解碼的該基因突變會(huì)增加風(fēng)險(xiǎn)的疾病種類（中文版）：

正在通過基因解碼技術(shù)進(jìn)行收集、查證并編輯，請(qǐng)關(guān)注佳學(xué)基因，獲得及時(shí)更新的人類基因序列變化與疾病表征數(shù)據(jù)庫(kù)的更新內(nèi)容

以該基因做靶點(diǎn)的藥物（國(guó)際版）：

Ziprasidone (Guanyl-nucleotide exchange factor activity);Amitriptyline (Guanyl-nucleotide exchange factor activity);Olanzapine (Guanyl-nucleotide exchange factor activity);Metixene (Guanyl-nucleotide exchange factor activity);Terfenadine (Guanyl-nucleotide exchange factor activity);Clozapine (Guanyl-nucleotide exchange factor activity);Trihexyphenidyl (Guanyl-nucleotide exchange factor activity);Procyclidine (Guanyl-nucleotide exchange factor activity);Loxapine (Guanyl-nucleotide exchange factor activity);Promazine (Guanyl-nucleotide exchange factor activity);Hyoscyamine (Guanyl-nucleotide exchange factor activity);Imipramine (Guanyl-nucleotide exchange factor activity);Darifenacin (Guanyl-nucleotide exchange factor activity);Nortriptyline (Guanyl-nucleotide exchange factor activity);Atropine (Guanyl-nucleotide exchange factor activity);Nicardipine (Guanyl-nucleotide exchange factor activity);Paroxetine (Guanyl-nucleotide exchange factor activity);Homatropine Methylbromide (Guanyl-nucleotide exchange factor activity);Scopolamine (Guanyl-nucleotide exchange factor activity);Benzquinamide (Guanyl-nucleotide exchange factor activity);Propiomazine (Guanyl-nucleotide exchange factor activity);Cryptenamine (Guanyl-nucleotide exchange factor activity);Tropicamide (Guanyl-nucleotide exchange factor activity);Brompheniramine (Guanyl-nucleotide exchange factor activity);Maprotiline (Guanyl-nucleotide exchange factor activity);Tolterodine (Guanyl-nucleotide exchange factor activity);Promethazine (Guanyl-nucleotide exchange factor activity);Doxepin (Guanyl-nucleotide exchange factor activity);Desipramine (Guanyl-nucleotide exchange factor activity);Quetiapine (Guanyl-nucleotide exchange factor activity);Aripiprazole (Guanyl-nucleotide exchange factor activity);Chlorprothixene (Guanyl-nucleotide exchange factor activity);Methotrimeprazine (Guanyl-nucleotide exchange factor activity);Solifenacin (Guanyl-nucleotide exchange factor activity);Isopropamide (Guanyl-nucleotide exchange factor activity);ALKS 27 (Guanyl-nucleotide exchange factor activity);Fesoterodine (Guanyl-nucleotide exchange factor activity);Aclidinium (Guanyl-nucleotide exchange factor activity);Umeclidinium (Guanyl-nucleotide exchange factor activity)

針對(duì)該基因所產(chǎn)生的突變，可能有正確效果的藥物（中文版）：

齊拉西酮（胍基-核苷酸交換因子活性）；阿米替林（胍基-核苷酸交換因子活性）；奧氮平（胍基-核苷酸交換因子活性）；Metixene（胍基-核苷酸交換因子活性）；特非那定（胍基-核苷酸交換因子活性）；氯氮平（胍基-核苷酸交換因子活性）；苯海索（胍基-核苷酸交換因子活性）；丙環(huán)利定（胍基-核苷酸交換因子活性）；洛沙平（胍基-核苷酸交換因子活性）；異丙嗪（胍基-核苷酸交換因子活性）；芍藥胺（胍基-核苷酸交換因子活性）；丙咪嗪（胍基-核苷酸交換因子活性）；達(dá)非那新（胍基-核苷酸交換因子活性）；去甲替林（胍基-核苷酸交換因子活性）；阿托品（胍基-核苷酸交換因子活性）；尼卡地平（胍基-核苷酸交換因子活性）；帕羅西?。一?核苷酸交換因子活性）；后馬托品甲基溴（胍基-核苷酸交換因子活性）；東莨菪堿（胍基-核苷酸交換因子活性）；苯醌（胍基-核苷酸交換因子活性） ;Propiomazine（胍基-核苷酸交換因子活性）；Cryptenamine（胍基-核苷酸交換因子活性）；Tropicamide（胍基-核苷酸交換因子活性）；Brompheniramine（胍基-核苷酸交換因子活性）；馬普替林（胍基-核苷酸交換因子活性） ;托特羅定（胍基-核苷酸交換因子活性）；異丙嗪（胍基-核苷酸交換因子活性）；多塞平（胍基-核苷酸交換因子活性）；地昔帕明（胍基-核苷酸交換因子活性）；喹硫平（胍基-核苷酸交換因子活性） ;Aripiprazole (Guanyl-nucleotide exchange factor activity);Chlorprothixene (Guanyl-nucleotide exchange factor activity);Methotrimeprazine (Guanyl-nucleotide exchange factor activity);Solifenacin (Guanyl-nucleotide exchange factor activity);Isopropamide (Guanyl-nucleotide exchange factor activity) ;ALKS 27（胍基-核苷酸交換因子活性）；非索羅定（胍基-核苷酸交換因子活性）；阿地溴銨（胍基-核苷酸交換因子活性）；烏美溴銨（胍基-核苷酸交換因子活性）