【佳學(xué)基因檢測(cè)】疾病 風(fēng)險(xiǎn)評(píng)估套餐是否應(yīng)當(dāng)有FGF10基因？

基因檢測(cè)的序列名稱：

FGF10

人體基因序列變化與疾病表征數(shù)據(jù)庫(kù)中的基因代碼：

2255

人體基因序列數(shù)據(jù)庫(kù)中國(guó)際交流名稱全稱

fibroblast growth factor 10

中國(guó)數(shù)據(jù)庫(kù)中基因全稱：

成纖維細(xì)胞生長(zhǎng)因子10

基因檢測(cè)報(bào)告英文版基因簡(jiǎn)介

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

基因突變所影響的基因信息

該基因編碼的蛋白質(zhì)是成纖維細(xì)胞生長(zhǎng)因子（FGF）家族的成員。FGF家族成員具有廣泛的促有絲分裂和細(xì)胞存活活性，并參與多種生物學(xué)過(guò)程，包括胚胎發(fā)育，細(xì)胞生長(zhǎng)，形態(tài)發(fā)生，組織修復(fù)，腫瘤生長(zhǎng)和侵襲。該蛋白對(duì)角質(zhì)化表皮細(xì)胞顯示有絲分裂活性，但對(duì)成纖維細(xì)胞基本上無(wú)活性，這與FGF7的生物學(xué)活性相似。小鼠同源物的研究表明，該基因是胚胎表皮形態(tài)發(fā)生（包括腦發(fā)育，肺形態(tài)發(fā)生和lim芽形成的起始）所必需的。該基因也被認(rèn)為是傷口愈合過(guò)程中的主要因素。[由RefSeq提供，2008年7月]

國(guó)際國(guó)內(nèi)該堿基基因序列的其他英語(yǔ)文字母簡(jiǎn)稱：

正在通過(guò)基因解碼技術(shù)進(jìn)行收集、查證并編輯，請(qǐng)關(guān)注佳學(xué)基因，獲得及時(shí)更新的人類基因序列變化與疾病表征數(shù)據(jù)庫(kù)的更新內(nèi)容

基因解碼對(duì)該基因序列在細(xì)胞核中的染色體所給予的編號(hào)：

該基因序列位于人類第5號(hào)染色體上。

基因解碼對(duì)基因序列的正確定位

該基因序列在GRCh37版本中的起始位置坐標(biāo)為：44305004；結(jié)束位置坐標(biāo)為：44389808。該基因序列在GRCh38版本中的起始位置坐標(biāo)為：44301655；結(jié)束位置坐標(biāo)為：44389780。正確的基因信息定位是基因檢測(cè)和對(duì)檢測(cè)結(jié)果進(jìn)行正確解讀的關(guān)鍵。

佳學(xué)基因解碼對(duì)該基因的功能分類：國(guó)際版

RAS pathway related proteins

基因解碼對(duì)該基因的功能分類：中文版

RAS通路相關(guān)蛋白

結(jié)構(gòu)與功能基因解碼所揭示的該基因在細(xì)胞內(nèi)發(fā)揮作用的場(chǎng)所（國(guó)際版）：

結(jié)構(gòu)與功能基因解碼所揭示的該基因發(fā)揮作用的細(xì)胞內(nèi)位置（中文版）：

該基因序列變化后增加的疾病風(fēng)險(xiǎn)（國(guó)際版）：

Aplasia of Lacrimal and Salivary Glands; Absence of the parotid gland; Absent proximal phalanx of thumb; Aplasia of the parotid gland; Bilateral triphalangeal thumbs; Hypoplasia of the lacrimal puncta; Hypoplastic lacrimal duct; Hypoplastic lacrimal gland; Iridocele; Lacrimal gland aplasia; Lacrimoauriculodentodigital syndrome; Nephrosclerosis; Parotid gland hypoplasia; Absence of Stensen duct; Agenesis of parotid duct; Agenesis of punctum lacrimale; Coronal hypospadias; Dacryocystitis; Lacrimal Puncta, Absence of; Radial deviation of the 3rd finger; Subcoronal hypospadias; Thenar hypoplasia; Partial duplication of thumb phalanx; Peg shaped front tooth; Peg-shaped incisors; Pointed front tooth; Pointed incisor; Radial polydactyly; Alacrima; Lacrimal Duct Obstruction; Obstruction of nasolacrimal duct; Periorbital fullness; Simple syndactyly of fingers - first web; Delayed eruption of primary teeth; Epithelial corneal erosions; Hearing Loss, Mixed Conductive-Sensorineural; Recurrent erosion of cornea; Absence of radius and ulna; Absent radius; Corneal Ulcer; Radial aplasia; Capuchin ears; Cupped ears (finding); Congenital hypoplasia of radius; Radial ray hypoplasia; Short ulnae; ULNAR HYPOPLASIA; Broad hallux; Congenital absence of kidney; Skin hyperelastic; Defective enamel matrix; Dental Enamel Hypoplasia; Dysplasia of tooth enamel; Thin dental enamel; Xerostomia; Broad forehead; Telecanthus; Dental caries; Rotting teeth; Cleft Lip; Hypodontia; Bilateral fifth finger clinodactyly; Curvature of little finger; Downward slant of palpebral fissure; Cleft Palate; Orbital separation excessive; Mammary Neoplasms; Prostatic Neoplasms

如果該基因突變后，風(fēng)險(xiǎn)可能增加的疾病類型（中文版）：

淚腺和唾液腺發(fā)育不全；沒(méi)有腮腺;沒(méi)有拇指的近節(jié)指骨；腮腺發(fā)育不全;雙側(cè)三指拇指；淚點(diǎn)發(fā)育不全;淚道發(fā)育不全；淚腺發(fā)育不全；虹膜膨出；淚腺發(fā)育不全；淚耳齒指綜合癥；腎硬化；腮腺發(fā)育不全;沒(méi)有 Stensen 導(dǎo)管；腮腺管發(fā)育不全；淚點(diǎn)發(fā)育不全；冠狀尿道下裂;淚囊炎;淚點(diǎn)缺失；第三指橈偏；冠狀下尿道下裂；魚(yú)際發(fā)育不全;拇指節(jié)部分重復(fù)；釘形門牙；釘形門牙；尖的門牙；尖門牙；橈骨多指；淚腺;淚道阻塞；鼻淚管阻塞；眶周豐滿度；手指的簡(jiǎn)單并指 - 先進(jìn)網(wǎng);乳牙延遲萌出；上皮角膜糜爛;聽(tīng)力損失混合傳導(dǎo)-感覺(jué)神經(jīng)性；角膜反復(fù)糜爛;沒(méi)有橈骨和尺骨；缺少半徑；角膜潰瘍；放射狀發(fā)育不全；卷尾猴的耳朵；杯狀耳朵（發(fā)現(xiàn)）；先天性橈骨發(fā)育不全；放射線發(fā)育不全；短尺骨；尺骨發(fā)育不全；大拇指；先天性無(wú)腎；皮膚超彈性；牙釉質(zhì)基質(zhì)缺陷；牙釉質(zhì)發(fā)育不全；牙釉質(zhì)發(fā)育不良;薄牙釉質(zhì)；口干;額頭寬闊；內(nèi)眥贅皮；齲齒;蛀牙;唇裂；缺牙癥;雙側(cè)小指彎曲；小指彎曲；瞼裂向下傾斜；腭裂；軌道分離過(guò)度；乳腺腫瘤；前列腺腫瘤

GWAS基因檢測(cè)所建立的與該基因的疾病關(guān)聯(lián)（國(guó)際版）：

Brain;Prostatic Neoplasms

GWAS基因檢測(cè)所解碼的該基因突變會(huì)增加風(fēng)險(xiǎn)的疾病種類（中文版）：

腦；前列腺腫瘤

以該基因做靶點(diǎn)的藥物（國(guó)際版）：

針對(duì)該基因所產(chǎn)生的突變，可能有正確效果的藥物（中文版）：

疾病風(fēng)險(xiǎn)評(píng)估套餐是否應(yīng)當(dāng)有FGF10基因？

(責(zé)任編輯：佳學(xué)基因)

【佳學(xué)基因檢測(cè)】疾病風(fēng)險(xiǎn)評(píng)估套餐是否應(yīng)當(dāng)有FGF10基因？

【佳學(xué)基因檢測(cè)】疾病風(fēng)險(xiǎn)評(píng)估套餐是否應(yīng)當(dāng)有FGF10基因？